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Despite a recent recommendation that hemoglobin A1c (HbA1c) be used as a standard diagnostic test for diabetes, the proposed diagnostic criteria fail to pick up a significant number of cases of diabetes and prediabetes, investigators reported at the 70th Annual Scientific Sessions of the American Diabetes Association.
Birth defects which have been documented following Accutane exposure include abnormalities of the face, eyes, ears, skull, central nervous system, cardiovascular system, and thymus and parathyroid glands. Cases of IQ scores less than 85 with or without other abnormalities have been reported. There is an increased risk of spontaneous abortion, and premature births have been reported.

 

She emphasized, however, that the HbA1c remains a useful tool for monitoring diabetes.
Because of Accutane's teratogenicity and to minimize fetal exposure, Accutane is approved for marketing only under a special restricted distribution program approved by the Food and Drug Administration. Accutane must only be prescribed by prescribers who are registered and activated with the iPLEDGE program. Accutane must only be dispensed by a pharmacy registered and activated with iPLEDGE, and must only be dispensed to patients who are registered and meet all the requirements.

 

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